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Title of Journal: Heart Vessels

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Abbravation: Heart and Vessels

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Springer Japan

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Ox-LDL can enhance the interaction of mice natural killer cells and dendritic cells via the CD48-2B4 pathway

Authors: Kan Dong, Jun-Hua Ge, Shu-Lian Gu, Shan Li, Wei-Guo Zhu, Fang-Yan Fan, Jian-Hua Zhu,

Publish Date: 2011/01/08
Volume: 26, Issue:6, Pages: 637-645
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The importance of the interaction between natural killer (NK) cells and dendritic cells (DCs) in the expansion of antiviral and antitumor immune responses is well documented; however, limited information on NK/DC interaction during atherosclerosis is available. Inflammation plays an important role in the development of atherosclerosis, and oxidized low-density lipoprotein (ox-LDL) is believed to play a critical role in the development and progression of atherosclerosis. In this study, we developed a NK/DC coculture system to examine the role of ox-LDL in modulating the interaction of mice NK cells and DCs. Fresh NK cells were cocultured with DCs in the absence or presence of ox-LDL. We examined the cytokines released during the interaction. This report provides the first evidence of an enhancement effect by ox-LDL on the NK/DC crosstalk. Notably, we found that ox-LDL significantly promoted the interaction of NK cells and DCs via CD48-2B4 contact-dependent mechanisms. These findings highlight the importance of NK/DCs crosstalk in atherosclerosis and provide new information about the possible mechanisms of atherosclerosis.



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