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Calcium Handling in hiPSC-Derived Cardiomyocytes

Authors: Lee Yee-Ki, Siu Chung-Wah,

Publish Date: 2012
Volume: , Issue:, Pages: 1-47
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Calcium is crucial in governing the contractile activities of myofilaments in cardiomyocytes. The characterization of calcium handling properties in human induced pluripotent stem cell–derived cardiomyocytes (iPSC-CMCs) is of significant interest and pertinent to the stem cell and cardiac regenerative field because of their potential patient-specific therapeutic use. In this book, readers can learn the approaches and parameters that have to be considered for calcium handling studies: these include the importance of the sarcoplasmic reticulum (SR), which governs the maturity of cardiomyocytes; the role of SR junctional proteins that facilitate calcium release and uptake through the SR; and the extent of immaturity of iPSC-CMCs compared with those derived from human embryonic stem cells in terms of calcium homeostasis. Future study would suggest potential uses of hiPSC-CMCs as a platform for cardiomyopathy disease modeling, especially certain cardiac defects related to impaired calcium homeostasis causing arrhythmia and pumping defeats. Last, a detailed protocol for calcium-sensitive dye calibration, calcium transient recording, and electrical contraction coupling is included.



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