Paper Search Console

Home Search Page Alphabetical List About Contact

Journal Title

Title of Journal:

Search In Journal Title:

Abbravation:

Search In Journal Abbravation:

Publisher

Springer, Berlin, Heidelberg

Search In Publisher:

ISSN

Search In ISSN:
Search In Title Of Papers:

Methods for Predicting RNA Secondary Structure

Authors: Kornelia Aigner, Fabian Dreßen, Gerhard Steger,

Publish Date: 2012
Volume: , Issue:, Pages: 19-41
PDF Link

Abstract

The formation of RNA structure is a hierarchical process: the secondary structure builds up by thermodynamically favorable stacks of base pairs (helix formation) and unfavorable loops (non-Watson–Crick base pairs; hairpin, internal, and bulge loops; junctions). The tertiary structure folds on top of the thermodynamically optimal or close-to-optimal secondary structure by formation of pseudoknots, base triples, and/or stacking of helices. In this chapter, we will concentrate on available algorithms and tools for calculating RNA secondary structures as the basis for further prediction or experimental determination of higher order structures. We give an introduction to the thermodynamic RNA folding model and an overview of methods to predict thermodynamically optimal and suboptimal secondary structures (with and without pseudoknots) for a single RNA. Furthermore, we summarize methods that predict a common or consensus structure for a set of homologous RNAs; such methods take advantage of the fact that the structures of noncoding RNAs are more conserved and more critical for their biological function than their sequences.


Keywords:

References


.
Search In Abstract Of Papers:
Other Papers In This Journal:


Search Result:



Help video to use 'Paper Search Console'