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Title of Journal: J Thromb Thrombolysis

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Abbravation: Journal of Thrombosis and Thrombolysis

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Springer US

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DOI

10.1007/s00066-013-0330-5

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ISSN

1573-742X

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Biomarkers of deep venous thrombosis

Authors: Huacheng Hou Zhijuan Ge Pu Ying Jin Dai Dongquan Shi Zhihong Xu Dongyang Chen Qing Jiang
Publish Date: 2012/04/12
Volume: 34, Issue: 3, Pages: 335-346
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Abstract

Deep venous thrombosis DVT which is associated with pulmonary embolism is a fatal disease because of its high morbidity and mortality in outpatients and inpatients especially in hospitalized patients At the same time lack of subjective clinical symptoms and objective clinical signs makes the diagnosis complicated Historically the primarily imaging modalities including duplex ultrasound helical CT scans and venography establish the diagnosis of DVT Currently both imaging modalities and serology are utilized These plasma molecules are regarded as the biomarkers of DVT including Ddimer Pselectin Factor VIII thrombin generation inflammatory cytokines microparticles fibrin monomer leukocyte count and so on This brief review is used to analyze the contribution of the biomarkers to diagnosis and guidance of therapy for DVT

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