Evaluation of drug–drug interaction screening soft

Authors: Cristiano S Moura Nília M Prado Najara O Belo Francisco A Acurcio

Publish Date: 2012/04/26

Volume: 34, Issue: 4, Pages: 547-552

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Abstract

Background Drugdrug interactions DDI in hospitalized patients are highly prevalent and an important source of adverse drug reactions DI computerized screening system can prevent the occurrence of some of these events Objective To evaluate the impact of drug–drug interaction DDI screening software combined with active intervention in preventing drug interactions Setting The study was conducted at General Hospital of Vitória da Conquista HGVC Brazil Method A quasiexperimental study was used to evaluate the impact of IMPharma a locally developed drug–drug interaction screening system coupled with pharmacist intervention on adverse drug events in the hospital setting Main outcome measure The proportion of patients coprescribed two interacting drugs were measured in two phases prior the implementation of IMPharma and during the intervention period DDI rates per 100 patient days were calculated before and after implementation Risk ratios were estimated by Poisson regression models Results A total of 6834 instances of drug–drug interactions were identified there was an average of 33 DDIs per patient in phase one and 25 in phase two a reduction of 24  P = 003 There was a 71  reduction in highseverity drug–drug interaction P  001 The risk for all DDIs decreased 50  after the implementation of IMPharma P  001 and for those with highseverity the reduction was 81  P  001 Conclusion The performance of IMPharma combined with pharmacist intervention was positive with an expressive reduction in the risk of DDIsThe authors thank undergraduate students Ludmila Tavares Jessica Bomfim Luana Costa and Priscila Porto for their participation in collecting data and Andre Barboni and his team from State University of Feira de Santana who collaborated in the development of the DDI screening software

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