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Title of Journal: Clin. Immunother.

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Abbravation: Clinical Immunotherapeutics

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Springer International Publishing

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10.1002/ajoc.201290001

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1179-190X

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Atopic Dermatitis

Authors: Kue-Hsiung Hsieh,

Publish Date: 2012/10/30
Volume: 3, Issue:1, Pages: 88-93
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Abstract

Atopic dermatitis is a chronic cutaneous inflammatory disease characterised by early age of onset, severe pruritus, a typical morphology and distribution of skin rash, chronic relapsing course, positive family history of atopy, and low thresholds for pruritogenic stimuli. Conventional treatment, including antihistamines, topical corticosteroids and control of superinfection, usually cannot prevent its chronic relapsing course.Recent knowledge about the nature of the inflammatory response in lesional skin and the inherited immunological abnormalities has prompted the empirical use of a wide variety of immunomodulatory agents in the treatment of patients with atopic dermatitis. These agents include thymopentin, interferon-α, interferon-γ interleukin-2 and systemic immunosuppressants such as cyclosporin. Nearly all of these agents show transient therapeutic effects during the course of treatment; however, the disease usually relapses after discontinuation of the therapy.Clinical trials with more patients and a prolonged treatment period, as well as more studies of the immunology of the disease, are needed to clarify the mechanisms of actions of these immunomodulatory agents and the rationale for their use in the treatment of atopic dermatitis.


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