Teriparatide Therapy for BisphosphonateAssociated

Authors: Jun Iwamoto Kaori Yago Yoshihiro Sato Hideo Matsumoto

Publish Date: 2012/12/13

Volume: 32, Issue: 8, Pages: 547-553

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Abstract

We report on the case of a severely osteoporotic elderly Japanese woman with bisphosphonateassociated osteonecrosis of the jaw ONJ who was treated successfully with teriparatide A 79yearold woman with severe osteoporosis and bisphosphonateassociated ONJ was treated with teriparatide after debridement of the necrotic tissue in the jaw bone Computed tomography CT images revealed the bone defect in the mandible after debridement of the necrotic tissue associated with ONJ According to the attending dentist the ONJ healed after 2 months of therapy After 3 months of treatment a robust increase in the serum level of the bone formation marker serum intact procollagen type 1 Nterminal propeptide was noted and a repeat CT revealed improvement of the bone defect of the mandible These results suggest the beneficial effects of teriparatide therapy in the severely osteoporotic elderly woman with ONJ

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