Vascular Dysfunction in Hypertension Revealed by F

Authors: Michael Carl Desiderio Russell M Mordecai Jean Walker Carl E Hock

Publish Date: 2013/04/16

Volume: 4, Issue: 2, Pages: 209-219

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Abstract

Impedance measurements have been used to quantify changes in vascular function associated with hypertension Fourier analysis based solely on the arterial flow wave may provide a useful alternative to traditional techniques Therefore the utility of blood flow frequency analysis in differentiating vascular changes in hypertension is tested A frequencybased method was developed to evaluate the aortic pulse wave under conditions of spontaneous hypertension sodium nitroprusside SNP induced normotension in spontaneously hypertensive rats SHR and phenylephrine PE induced hypertension in Wistar–Kyoto rats WKY Under anesthesia animals were instrumented and signals were digitized for measurement of arterial blood pressure aortic blood flow and electrocardiogram Hemodynamic parameters were extracted and the aortic flow signal was processed via Fourier analysis to produce a fingerprint of pulse transmission Results demonstrated significant fingerprint differences between SHR and WKY at baseline pressures Fingerprint differences are simulated by PEinduced hypertension however they did not match the SHR fingerprint despite similar flowbased biomarkers Conversely administration of SNP to the SHR creates differences in the fingerprint however SNP did not approximate the WKY fingerprint despite similar hemodynamics Furthermore characteristic fingerprint differences between SHR and WKY vasculature are maintained regardless of the intervention In conclusion results suggest Fourier analysis can be used to reveal functional vascular states regardless of pressure Data presented demonstrates functional differences in the hypertensive vasculature that cannot be ameliorated with SNP or reproduced with PE in normotensive vasculature This may be useful clinically to identify vascular dysfunction prior to overt hypertension

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