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Title of Journal: Intensive Care Med

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Abbravation: Intensive Care Medicine

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Springer Berlin Heidelberg

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DOI

10.1007/bf00493197

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1432-1238

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Higher mean arterial pressure with or without vasoactive agents is associated with increased survival and better neurological outcomes in comatose survivors of cardiac arrest

Authors: Marie E. Beylin, Sarah M. Perman, Benjamin S. Abella, Marion Leary, Frances S. Shofer, Anne V. Grossestreuer, David F. Gaieski,

Publish Date: 2013/08/31
Volume: 39, Issue:11, Pages: 1981-1988
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Abstract

The 2010 AHA Guidelines for Post-Cardiac Arrest Care recommend immediate treatment of hypotension to maintain adequate tissue perfusion with a goal of mean arterial pressure (MAP) of ≥65 mmHg. However, no studies exist examining the relationship between early hemodynamic goals and outcomes in post-cardiac arrest syndrome (PCAS) patients undergoing therapeutic hypothermia (TH). In this investigation, we examined the relationship between MAP, vasoactive agents, and survival or neurologic outcomes.Consecutive PCAS patients treated with algorithmic post-arrest care between 2005 and 2011 were included in this retrospective study. MAP and number of vasoactive agents were analyzed at 1, 6, 12, and 24 h after arrest. Primary outcome was survival at discharge. Data were analyzed using logistic regression analysis and ANOVA.Of 168 patients, 45 % (75/168) survived, and 35 % (58/168) had cerebral performance category (CPC) scores 1–2. Survivors had higher MAPs at 1 h (96 vs. 84 mmHg, p 


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