Journal Title
Title of Journal: Cancer Microenvironment
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Abbravation: Cancer Microenvironment
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Publisher
Springer Netherlands
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Authors: Arthur A Hurwitz Steven M Cuss Katherine E Stagliano Ziqiang Zhu
Publish Date: 2013/12/20
Volume: 7, Issue: 1-2, Pages: 1-9
Abstract
A potent T cell response is an important component of durable antitumor immunity The quality of the T cell response can inpart be measured by the avidity of the T cell for its tumor antigenexpressing target While convention suggests that raising the avidity of the responding T cells may make for a more potent antitumor immune response the threshold for effective tumor immunity remains unclear as do some of the adverse effects of an inappropriately high avidity response In this review we discuss the relationship between T cell avidity and antitumor immunity considering both experimental model systems as well as human clinical trials
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