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Publisher
Springer, Berlin, Heidelberg
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Authors: Göran K Hansson
Publish Date: 2014
Volume: , Issue: , Pages: 1-17
Abstract
Atherosclerosis is a chronic inflammatory disease elicited by the accumulation of cholesterolrich lipoproteins in the artery wall This review outlines its pathogenesis with a focus on molecular mechanisms mediating immunemetabolic interactions vascular inflammation formation of atherothrombi and triggering of clinical ischemic eventsAdaptive immunity is a highly specific system for the recognition and neutralization of pathogens it is initiated when antigenic fragments bound to MHC proteins on cell surfaces are recognized by unique Tcell receptors TCR Downstream thereof highly specific antibodies as well as cellmediated responses contribute to antigen elimination cell death and inflammation
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