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Title of Journal: JARO

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Abbravation: Journal of the Association for Research in Otolaryngology

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Springer US

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DOI

10.1002/ar.1092380111

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1438-7573

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Basilar Membrane and Tectorial Membrane Stiffness

Authors: I U Teudt C P Richter
Publish Date: 2014/05/28
Volume: 15, Issue: 5, Pages: 675-694
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Abstract

The mouse has become an important animal model in understanding cochlear function Structures such as the tectorial membrane or hair cells have been changed by gene manipulation and the resulting effect on cochlear function has been studied To contrast those findings physical properties of the basilar membrane BM and tectorial membrane TM in mice without gene mutation are of great importance Using the hemicochlea of CBA/CaJ mice we have demonstrated that tectorial membrane TM and basilar membrane BM revealed a stiffness gradient along the cochlea While a simple spring mass resonator predicts the change in the characteristic frequency of the BM the spring mass model does not predict the frequency change along the TM Plateau stiffness values of the TM were 06 ± 05 02 ± 01 and 009 ± 009 N/m for the basal middle and upper turns respectively The BM plateau stiffness values were 37 ± 22 12 ± 12 and 05 ± 05 N/m for the basal middle and upper turns respectively Estimations of the TM Young’s modulus in kPa revealed 243 ± 252 for the basal turns 51 ± 45 for the middle turns and 19 ± 16 for the apical turns Young’s modulus determined at the BM pectinate zone was 768 ± 72 239 ± 306 and 94 ± 62 kPa for the basal middle and apical turns respectively The reported stiffness values of the CBA/CaJ mouse TM and BM provide basic data for the physical properties of its organ of CortiThis work was supported by the American Hearing Research Foundation the Hugh Knowles Center the National Science Foundation IBN077476 and IBN0415901 and the NIH DC0008944 to MAC The authors thank Dr Peter Dallos for providing equipment and support to accomplish the experiments and for feedback on an earlier version of the manuscript


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Other Papers In This Journal:

  1. Orientation of Human Semicircular Canals Measured by Three-Dimensional Multiplanar CT Reconstruction
  2. Relative Time Course of Degeneration of Different Cochlear Structures in the CD/1 Mouse Model of Accelerated Aging
  3. Altered Cortical Activity in Prelingually Deafened Cochlear Implant Users Following Long Periods of Auditory Deprivation
  4. A Quantitative Analysis of the Spatiotemporal Pattern of Transient Receptor Potential Gene Expression in the Developing Mouse Cochlea
  5. Basilar Membrane and Tectorial Membrane Stiffness in the CBA/CaJ Mouse
  6. Survival of Partially Differentiated Mouse Embryonic Stem Cells in the Scala Media of the Guinea Pig Cochlea
  7. Spectral and Temporal Analysis of Simulated Dead Regions in Cochlear Implants
  8. The Role of Age-Related Declines in Subcortical Auditory Processing in Speech Perception in Noise
  9. Spontaneous Basilar Membrane Oscillation and Otoacoustic Emission at 15 kHz in a Guinea Pig
  10. Purinergic Modulation of Cochlear Partition Resistance and Its Effect on the Endocochlear Potential in the Guinea Pig
  11. Electrical Excitation of the Acoustically Sensitive Auditory Nerve: Single-Fiber Responses to Electric Pulse Trains
  12. Examining the Electro-Neural Interface of Cochlear Implant Users Using Psychophysics, CT Scans, and Speech Understanding
  13. Gender Categorization Is Abnormal in Cochlear Implant Users
  14. Aural Acoustic Stapedius-Muscle Reflex Threshold Procedures to Test Human Infants and Adults
  15. Experimental Study of Vibrations of Gerbil Tympanic Membrane with Closed Middle Ear Cavity
  16. Forward Masking in Cochlear Implant Users: Electrophysiological and Psychophysical Data Using Pulse Train Maskers
  17. Cigarette Smoking, Passive Smoking, Alcohol Consumption, and Hearing Loss
  18. Subcortical Plasticity Following Perceptual Learning in a Pitch Discrimination Task

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