MTA family of proteins in DNA damage response mec

Authors: DaQiang Li Yinlong Yang Rakesh Kumar

Publish Date: 2014/10/21

Volume: 33, Issue: 4, Pages: 993-1000

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Abstract

The DNA damage most notably DNA doublestrand breaks poses a serious threat to the stability of mammalian genome Maintenance of genomic integrity is largely dependent on an efficient accurate and timely DNA damage response in the context of chromatin Consequently dysregulation of the DNA damage response machinery is fundamentally linked to the genomic instability and a likely predisposition to cancer In turn aberrant activation of DNA damage response pathways in human cancers enables tumor cells to survive DNA damages thus leading to the development of resistance of tumor cells to DNA damaging radio and chemotherapies A substantial body of experimental evidence has established that ATPdependent chromatin remodeling and histone modifications play a central role in the DNA damage response As a component of the nucleosome remodeling and histone deacetylase NuRD complex that couples both ATPdependent chromatin remodeling and histone deacetylase activities the metastasisassociated protein MTA family proteins have been recently shown to participate in the DNA damage response beyond its wellestablished roles in gene transcription In this thematic review we will focus on our current understandings of the role of the MTA family proteins in the DNA damage response and their potential implications in DNA damaging anticancer therapyWe are in debt to our colleagues in this field whose original work may have not been cited here due to space limitations This study was supported by the Program for Professor of Special Appointment Eastern Scholar at Shanghai Institutions of Higher Learning No 2013–06 to DQ L and NIH grants CA98823 to RK

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