Longterm results of oxybutynin treatment for palm

Authors: Nelson Wolosker Marcelo Passos Teivelis Mariana Krutman Rafael P de Paula José R M de Campos Paulo Kauffman Pedro PuechLeão

Publish Date: 2014/11/27

Volume: 24, Issue: 6, Pages: 297-303

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Abstract

Palmar hyperhidrosis PH is a common illness that significantly impacts Quality of Life QOL Oxybutynin offers excellent shortterm results but longterm followup results are limited We evaluated its effectiveness in a large group of patients who did not have surgery and who had at least 6 months of followupBetween September 2007 and September 2013 570 consecutive patients were enrolled in our institutional protocol regarding the “pharmacologicalfirst” treatment of primary PH with oxybutynin Fiftynine were lost to followup and the data were available for 511 patients treated for at least 6 weeks Data recorded at the start of the protocol 6 weeks after beginning treatment and during patients’ final visits were analyzed112 patients 219  did not improve and were referred for surgery sympathectomy Eight 156  developed significant side effects eg dry mouth and discontinued therapy Thirty 59  preferred surgery over pharmacological treatment 111 have not yet received treatment for 6 months The 246 patients with more than 6 months of followup median 16 months range 6–72 were analyzed as follows 902  experienced moderate or great improvement in their PH 9034  experienced improvement at other sites of hyperhidrosis following a median of 16 monthsAmong patients with good initial responses to oxybutynin more than 90  experienced moderate or great improvement in their palmar sweating as well as in their hyperhidrosis in other sites after 6 months The results were particularly favorable in those patients with BMI 25 kg/m2 and in those who noted an improved QOL after 6 weeks

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