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Title of Journal: Drug Saf

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Abbravation: Drug Safety

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Springer International Publishing

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DOI

10.1016/j.bbrc.2014.03.143

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1179-1942

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Antipsychotic Drug Exposure and Risk of Venous Thr

Authors: Corrado Barbui Valentino Conti Andrea Cipriani
Publish Date: 2014/01/09
Volume: 37, Issue: 2, Pages: 79-90
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Abstract

Venous thromboembolism VTE is a serious disorder that may be complicated by pulmonary embolism PE Case reports and observational studies published in the early 1950s suggested that antipsychotic AP drugs may represent a risk factor while observational studies conducted in the last 3 decades have provided conflicting resultsAntipsychotic exposure was associated with a significant increase in risk of developing VTE odds ratio OR 154 95  confidence interval CI 128–186 11 studies Exposure to APs did not significantly increase the risk of PE OR 490 95  CI 077–3098 three studies but the overall estimate was highly heterogeneous and the CI included the possibility of substantial harm Randomeffects metaanalysis on the risk of VTE associated with exposure to first OR 174 95  CI 128–237 six studies and secondgeneration OR 207 95  CI 174–252 five studies APs revealed an increased risk Only a few studies provided data on individual drugs and estimates of effect were very uncertainAntipsychotic exposure in unselected patient populations may be associated with a 50  increase in the risk of developing VTE However betweenstudy heterogeneity limits the confidence in this estimate This increased risk similarly applies to first and secondgeneration AP drugs

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