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Publisher
Humana Press, New York, NY
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Authors: João S Teodoro Carlos M Palmeira Anabela P Rolo
Publish Date: 2015
Volume: , Issue: , Pages: 71-84
Abstract
Mitochondria possess a genome that codes for proteins in the same fashion as the nuclear genome However the small circular mitochondrial DNA mtDNA molecule has a reduced base pair content for it can only code for 2 rRNA 22 tRNA molecules and 13 proteins all of them part of the mitochondrial respiratory chain As such all of the other mitochondrial components derive from nuclear genome This separation leads to a requirement for a welltuned coordination between both genomes in order to produce fully functional mitochondria A vast number of pathologies have been demonstrated to involve to some extent alterations in mitochondrial function that no doubt can be caused by alterations to the respiratory chain activity As such several methods and techniques have been developed to assess both content and function of mitochondrial proteins in order to help understand mitochondrial involvement on the pathogenesis of disease In this chapter we will address some of these methods with the main focus being on isolated mitochondria
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