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Authors: Gessica Sala Giovanni Stefanoni Daniele Marinig Carlo Ferrarese
Publish Date: 2015
Volume: , Issue: , Pages: 225-245
Abstract
This chapter is intended to provide an organic revision of evidence for the involvement of autophagy in the pathogenesis of rotenoneinduced toxicity The mechanisms underlying rotenone neurotoxicity are elucidated through a description of findings obtained in both in vivo and in vitro experimental models Furthermore this chapter describes the etiological role of rotenone and other pesticide exposure in the pathogenesis of Parkinson’s disease as demonstrated by epidemiological studies performed in the last decades starting from results obtained in animal and cellular experimental models The specific focus of the present chapter is to explore the effect of rotenone on autophagic pathway whose dysfunctions are already recognized to play an important pathogenetic role in Parkinson’s disease Specifically a comprehensive revision of the current available literature on the rotenoneinduced dysfunctions of the two main types of autophagy macroautophagy and chaperonemediated autophagy is provided in order to clarify the protective rather than detrimental contribute exerted by autophagy alterations in the cell death induced by rotenone
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