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Springer, Berlin, Heidelberg

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10.1016/j.aca.2010.09.028

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Nonbehavioral Methods Used in the Study of Learning and Memory

Authors: F. Scott Hall,

Publish Date: 2015
Volume: , Issue:, Pages: 1-46
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Abstract

Acetylcholinesterase (AChE), which is sometimes called true or specific cholinesterase, is found in nerve cells, skeletal muscle, smooth muscle, various glands, and red blood cells (Nachmansohn and Rothenberg 1945; Koelle et al. 1950; Ellman et al. 1961). AChE may be distinguished from other cholinesterases by substrate and inhibitor specificities and by regional distribution. Its distribution in brain roughly correlates with cholinergic innervation, and subfractionation shows the highest level in nerve terminals.It is generally accepted that the physiological role of AChE is the rapid hydrolysis and inactivation of acetylcholine. Inhibitors of AChE show marked cholinomimetic effects in cholinergically innervated effector organs (Taylor 1996) and have been used therapeutically in the treatment of glaucoma, myasthenia gravis, and paralytic ileus. However, recent studies (Christie et al. 1981; Summers et al. 1981; Davies and Mohs 1982; Atak et al. 1983) have suggested that AChE inhibitors may also be beneficial in the treatment of Alzheimer’s dementia.


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