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Title of Journal: Curr Allergy Asthma Rep

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Abbravation: Current Allergy and Asthma Reports

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Springer US

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DOI

10.1016/0020-711x(75)90036-1

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1534-6315

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Severe Asthma in School-Age Children: Evaluation and Phenotypic Advances

Authors: Andrea Coverstone, Leonard B. Bacharier, Anne M. Fitzpatrick,

Publish Date: 2015/07/02
Volume: 15, Issue:5, Pages: 20-
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Abstract

Although the majority of children with asthma have a favorable clinical response to treatment with low to moderate doses of inhaled corticosteroids (ICS), a small subset of children have “severe” asthma characterized by ongoing symptoms and airway inflammation despite treatment with high doses of ICS and even oral corticosteroids. Although there is symptom heterogeneity in the affected children, children with severe asthma share the risk for adverse outcomes, including recurrent and potentially life-threatening exacerbations, which contribute to substantial economic burden. This article reviews current knowledge of severe asthma in school-age children (age 6–17 years) with a focus on recent literature published after January 2012. Clinical management approaches for children with severe asthma are discussed as well as current phenotyping efforts and emerging phenotypic-directed therapies that may be of benefit for subpopulations of children with severe asthma in the future.Leonard B. Bacharier reports consultancies from Aerocrine, GlaxoSmithKline, Genentech/Novartis, Merck, Schering, Cephalon, DBV Technologies, and Teva. Anne M. Fitzpatrick reports consultancies from MedImmune, Merck, GlaxoSmithKline, Genentech, and Boehringer Ingelheim. Andrea Coverstone declares no conflict of interest.


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