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Title of Journal: Cell Tissue Res

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Abbravation: Cell and Tissue Research

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Springer Berlin Heidelberg

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Characterization of miRNA processing machinery in the embryonic chick lung

Authors: Rute Silva Moura, Patrícia Vaz-Cunha, Carla Silva-Gonçalves, Jorge Correia-Pinto,

Publish Date: 2015/07/23
Volume: 362, Issue:3, Pages: 569-575
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Lung development is a very complex process that relies on the interaction of several signaling pathways that are controlled by precise regulatory mechanisms. Recently, microRNAs (miRNAs), small non-coding regulatory RNAs, have emerged as new players involved in gene expression regulation controlling several biological processes, such as cellular differentiation, apoptosis and organogenesis, in both developmental and disease processes. Failure to correctly express some specific miRNAs or a component of their biosynthetic machinery during embryonic development is disastrous, resulting in severe abnormalities. Several miRNAs have already been identified as modulators of lung development. Regarding the spatial distribution of the processing machinery of miRNAs, only two of its members (dicer1 and argonaute) have been characterized. The present work characterizes the expression pattern of drosha, dgcr8, exportin-5 and dicer1 in early stages of the embryonic chick lung by whole mount in situ hybridization and cross-section analysis. Overall, these genes are co-expressed in dorsal and distal mesenchyme and also in growing epithelial regions. The expression pattern of miRNA processing machinery supports the previously recognized regulatory role of this mechanism in epithelial and mesenchymal morphogenesis.



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  1. Changes in mammary fat pad composition and lipolytic capacity throughout pregnancy
  2. Neuroimmunomodulation in human autoimmune liver disease
  3. Transcription factor PEX1 modulates extracellular matrix turnover through regulation of MMP-9 expression
  4. Fusion failure of dense-cored proacrosomal vesicles in an inducible mouse model of male infertility
  5. The roles of tumor- and metastasis-promoting carcinoma-associated fibroblasts in human carcinomas
  6. Segregation of neuronal and neuroendocrine differentiation in the sympathoadrenal lineage
  7. The TIM23 mitochondrial protein import complex: function and dysfunction
  8. The effect of the transplanted pineal gland on the sympathetic innervation of the rat sublingual gland
  9. Transcription factor Yin-Yang 2 alters neuronal outgrowth in vitro
  10. Lack of TrkB and TrkC signaling alters the synaptogenesis and maturation of mossy fiber terminals in the hippocampus
  11. Immunohistochemical distribution of proteins belonging to the receptor-mediated and the mitochondrial apoptotic pathways in human placenta during gestation
  12. Differential expression of the bone and the liver tissue non-specific alkaline phosphatase isoforms in brain tissues
  13. Thymic alterations in mice deficient for the SNARE protein VAMP8/endobrevin
  14. Tenogenic differentiation of equine adipose-tissue-derived stem cells under the influence of tensile strain
  15. Agrin becomes concentrated at neuroeffector junctions in developing rodent urinary bladder
  16. Cultured gastrointestinal smooth muscle cells: cell response to contractile agonists depends on their phenotypic state
  17. Impact of extracellular RNA on endothelial barrier function
  18. Characterization of miRNA processing machinery in the embryonic chick lung

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