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Title of Journal: J Therm Anal Calorim

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Abbravation: Journal of Thermal Analysis and Calorimetry

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Springer Netherlands

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DSC kinetic study of the incompatibility of doxepin with dextrose

Authors: Faranak Ghaderi, Mahboob Nemati, Mohammad R. Siahi-Shadbad, Hadi Valizadeh, Farnaz Monajjemzadeh,

Publish Date: 2015/09/05
Volume: 123, Issue:3, Pages: 2081-2090
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In the present paper, the physicochemical incompatibility of doxepin with dextrose was evaluated in solid-state mixtures. The compatibility was evaluated using different physicochemical methods such as differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy and mass spectrometry. Non-isothermally stressed physical mixtures were used to study the solid-state kinetic parameters. Different thermal models such as Friedman, Flynn–Wall–Ozawa and Kissinger–Akahira–Sunose were used for the characterization of the drug–excipient mixtures. Overall, the incompatibility of doxepin as a tertiary amine with dextrose as a reducing carbohydrate was successfully assessed. DSC-based kinetic analysis is a simple and fast method in evaluation of different drug–excipient mixtures incompatibility. Finally, it can be recommended to exclude dextrose from doxepin pharmaceutical formulations and also to apply the easy and versatile DSC method in kinetic study of drug–excipient incompatibility.



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  1. Oxidation studies of Indian reduced activation ferritic martensitic steel
  2. Decomposition of perfluoropolyether lubricants
  3. Synthesis
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  5. Amorphous phase dynamics at the glass transition in drawn semi-crystalline polyester
  6. Calibration burning of wood crib under ISO9705 hood
  7. Influence of biomass on coal combustion based on thermogravimetry and Fourier transform infrared spectroscopy
  8. Isoconversional analysis of solid state transformations
  9. Investigation of copper(II) complexation by glycylglycine using isothermal titration calorimetry
  10. Flammability of diene rubbers
  11. Thermal deamination kinetics of tris(ethylenediamine)nickel(II) sulphate in the solid-state
  12. Preparation
  13. A review on the thermal stability of calcium apatites
  14. Thermal reaction characteristics of the boron used in the fuel-rich propellant
  15. Effects of stirring rate for thermal runaway reaction in cumene hydroperoxide manufacturing process using calorimetric techniques
  16. Statistical classification of early and late wood through the growth rings using thermogravimetric analysis
  17. Conjugate heat transfer analysis of knitted fabric
  18. Influences of fly ash and fluorgypsum on the hydration heat and compressive strength of cement
  19. Thermal conductivity of lightweight aggregate based on coal fly ash
  20. Calculations of thermal functions of group-III nitrides
  21. Antioxidant activity of 6PPD derivatives in polyisoprene matrix studied by non-isothermal DSC measurements
  22. Novel calorimetric properties of human cartilage samples in rheumatoid arthritis
  23. Synthesis
  24. Examination of the peripheral nerve and muscle damage in cyclophosphamide monotherapy with DSC in animal models
  25. Procedure for generation of catalyst-free PE-TG profiles and its consequence on calculated activation energies
  26. DSC study of glycerol-extracted muscle fibers in intermediate states of ATP hydrolysis
  27. Heat capacity of indium nitride
  28. A kinetic analysis of thermal decomposition of polyaniline and its composites with rare earth oxides
  29. A low-temperature heat capacity study of natural lithium micas
  30. Synthesis
  31. Sodium
  32. Palladium(II) complexes with 5-methyl-5-(4-pyridyl)-2
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  34. A combined approach of differential scanning calorimetry and hot-stage microscopy with image analysis in the investigation of sulfathiazole polymorphism
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  36. DSC kinetic study of the incompatibility of doxepin with dextrose
  37. Expanded graphite
  38. Elaborated molecular docking and DFT/B3LYP studies for novel sulfa drug complexes

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