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Title of Journal: J Therm Anal Calorim

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Abbravation: Journal of Thermal Analysis and Calorimetry

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Springer Netherlands

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DOI

10.1016/0016-0032(59)90711-2

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1588-2926

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DSC kinetic study of the incompatibility of doxepin with dextrose

Authors: Faranak Ghaderi, Mahboob Nemati, Mohammad R. Siahi-Shadbad, Hadi Valizadeh, Farnaz Monajjemzadeh,

Publish Date: 2015/09/05
Volume: 123, Issue:3, Pages: 2081-2090
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Abstract

In the present paper, the physicochemical incompatibility of doxepin with dextrose was evaluated in solid-state mixtures. The compatibility was evaluated using different physicochemical methods such as differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy and mass spectrometry. Non-isothermally stressed physical mixtures were used to study the solid-state kinetic parameters. Different thermal models such as Friedman, Flynn–Wall–Ozawa and Kissinger–Akahira–Sunose were used for the characterization of the drug–excipient mixtures. Overall, the incompatibility of doxepin as a tertiary amine with dextrose as a reducing carbohydrate was successfully assessed. DSC-based kinetic analysis is a simple and fast method in evaluation of different drug–excipient mixtures incompatibility. Finally, it can be recommended to exclude dextrose from doxepin pharmaceutical formulations and also to apply the easy and versatile DSC method in kinetic study of drug–excipient incompatibility.


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