Genotype 3 and higher lowdensity lipoprotein leve

Authors: Sanjiv Saigal Narendra S Choudhary Neeraj Saraf Dheeraj Gautam Lipika Lipi Amit Rastogi Sanjay Goja P Balachandran Menon Prashant Bhangui Sumana K Ramachandra Arvinder S Soin

Publish Date: 2015/09/23

Volume: 34, Issue: 4, Pages: 305-309

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Abstract

Treatment of recurrent hepatitis C after liver transplantation is associated with poor sustained virological response SVR in genotype 1 and data on genotype 3 is limited to small numbers We report one of the largest series of genotype 3 patients treated for recurrent hepatitis C following living donor liver transplantation LDLTFrom January 2002 to November 2013 of 1349 transplants 359 patients had hepatitis C Patients with histological recurrence were treated with pegylated interferon in escalating dose regimen for 48 weeks and weightbased ribavirin Virological response was defined as rapid virological response RVR—4 weeks early virological response EVR—12 weeks end of treatment response ETR—48 weeks and SVR 24 weeks after end of treatment SVR and noSVR groups were compared for age sex body mass index BMI diabetes total cholesterol lowdensity lipoprotein LDL highdensity lipoprotein HDL triglycerides ferritin genotype and hepatitis C virus HCV RNA levels before initiation of treatmentThe study included 67 patients who had at least 18 months of follow up after treatment initiation 45 males aged 51 ± 63 years Treatment was started after 16 months median baseline median RNA was 27 × 106 IU/mL There was no significant difference between the SVR and noSVR groups regarding age sex ratio follow up period total cholesterol triglycerides HDL BMI prevalence of diabetes HCV RNA and ferritin levels Genotype 3 RVR EVR ETR and higher LDL levels were significantly associated with SVR Genotype 3 had a significantly higher SVR rate of 71  as compared to an SVR rate of only 14  in genotype 1 p = 00003 Absence of RVR and EVR predicted treatment failure with a specificity of 88 and 92  respectively

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