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Title of Journal: Tumor Biol.

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Abbravation: Tumor Biology

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Springer Netherlands

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MicroRNA-608 acts as a prognostic marker and inhibits the cell proliferation in hepatocellular carcinoma by macrophage migration inhibitory factor

Authors: Kejia Wang, Qing Liang, Li Wei, Wei Zhang, Ping Zhu,

Publish Date: 2015/10/16
Volume: 37, Issue:3, Pages: 3823-3830
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Human hepatocellular carcinoma (HCC) is one of the most prevalent malignancies in the world. Research on HCC has recently focused on microRNAs (miRNAs) that play crucial roles in cancer development and progression of HCC. In this study, we aimed to analyze the expression and function of a metastasis-associated microRNA-608 (miR-608) in HCC. Samples of human HCC and matched adjacent normal tissues were surgically removed, and miR-608 expression and the pathological characteristics of HCC were investigated. In this study, we found that miR-608 expression was significantly reduced in HCC and its expression levels were highly associated with tumor size, differentiation, clinical stage, and overall and disease-free survival of HCC. Overexpression of miR-608 in HCC cell lines HepG2 and SK-Hep-1 inhibited cell proliferation by G1 arrest. Macrophage migration inhibitory factor (MIF), a potential target gene of miR-608, was inversely correlated with miR-608 expression in HCC tissues and cell lines. Furthermore, we demonstrated that MIF was directly regulated by miR-608 and the restoration of MIF expression reversed the inhibitory effects of miR-608 on HCC cell proliferation. Taken together, these findings collectively demonstrate that miR-608 exerts its anti-cancer function by directly targeting MIF in HCC, indicating a potential novel prognostic biomarker and therapeutic target for HCC.



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Other Papers In This Journal:

  1. MicroRNA-608 acts as a prognostic marker and inhibits the cell proliferation in hepatocellular carcinoma by macrophage migration inhibitory factor
  2. Interpretation of immunohistochemistry data of tumor should consider microenvironmental factors
  3. Interpretation of immunohistochemistry data of tumor should consider microenvironmental factors
  4. EphB4 is overexpressed in gliomas and promotes the growth of glioma cells
  5. Combination of platelet count and mean platelet volume (COP-MPV) predicts postoperative prognosis in both resectable early and advanced stage esophageal squamous cell cancer patients
  6. Complete loss of STAG2 expression is an indicator of good prognosis in patients with bladder cancer
  7. MicroRNA-486-5p targeting PIM-1 suppresses cell proliferation in breast cancer cells
  8. Aberrant regulation of miR-15b in human malignant tumors and its effects on the hallmarks of cancer
  9. Glutathione S-transferase P1 Ile105Val polymorphism contributes to increased risk of gastric cancer in East Asians
  10. Association of peripheral CD4+ CXCR5+ T cells with chronic lymphocytic leukemia
  11. miR-448 suppressed gastric cancer proliferation and invasion by regulating ADAM10
  12. IL-17 gene polymorphism is associated with susceptibility to gastric cancer
  13. SPAG9 is overexpressed in human astrocytoma and promotes cell proliferation and invasion
  14. Hexokinase 2 overexpression promotes the proliferation and survival of laryngeal squamous cell carcinoma
  15. Risk of gastrointestinal perforation in cancer patients treated with aflibercept: a systematic review and meta-analysis
  16. Overexpression of LARP1 predicts poor prognosis of colorectal cancer and is expected to be a potential therapeutic target
  17. Breast cancer risk in relation to TP53 codon 72 and CDH1 gene polymorphisms in the Bangladeshi women
  18. Interleukin-6 receptor in spindle-shaped stromal cells
  19. Endoglin (CD105) expression in ovarian serous carcinoma effusions is related to chemotherapy status
  20. HCC-DETECT: a combination of nuclear
  21. MicroRNA218 inhibits glioma migration and invasion via inhibiting glioma-associated oncogene homolog 1 expression at N terminus
  22. Prognostic significance of Bcl-2 expression in non-basal triple-negative breast cancer patients treated with anthracycline-based chemotherapy
  23. Overexpression of ADAMTS5 can regulate the migration and invasion of non-small cell lung cancer
  24. Alterations of circulating follicular helper T cells and interleukin 21 in diffuse large B-cell lymphoma
  25. Irradiation induces glioblastoma cell senescence and senescence-associated secretory phenotype
  26. Investigation of circulating antibodies to ANXA1 in breast cancer
  27. Association of RECQL5 gene polymorphisms and osteosarcoma in a Chinese Han population
  28. XRCC1 Arg399Gln polymorphism is not associated with oral cancer risk: evidence from a meta-analysis

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