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Title of Journal: Res Chem Intermed

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Abbravation: Research on Chemical Intermediates

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Syntheses of valpromide dipeptide derivatives and interactions of derivatives with ctDNA

Authors: Dongxin Zhao, Li Ma, Kui Lu, Jiangzhuo Wu, Juan He,

Publish Date: 2015/01/07
Volume: 41, Issue:11, Pages: 8591-8601
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Two types of valproamide dipeptides, i.e., valproic acid (VPA)-Tyr-Tyr and VPA-His-His, were synthesized via Fmoc solid-phase peptide synthesis, purified via reversed-phase HPLC, and characterized via 1H, 13C NMR and ESI–MS to promote the interaction of valproic acid derivative with biological molecular. The interactions of VPA-Tyr-Tyr and VPA-His-His with DNA were investigated via UV–Vis absorption spectroscopy, fluorescence spectroscopy, and gel electrophoresis. The results showed that both VPA-Tyr-Tyr and VPA-His-His interacted with ctDNA through the groove binding mode and exhibited higher affinity for ctDNA compared with free VPA. Therefore, the valpromide derivatives modified by dipeptides have significant practical value in future studies.We thank the National Natural Science Foundation of China (No. 21172054 and 21301050), the Innovation scientists and Technicians Troop construction projects of Zhengzhou city (No. 10LJRC174) and the Foundation of Education Department of Henan Province (No. 13B150947).



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