Journal Title
Title of Journal:
|
|
|
|
|
|
|
|
|
|
Authors: Katharina Held Thomas Voets Joris Vriens
Publish Date: 2016
Volume: , Issue: , Pages: 67-99
Abstract
Opening and closing of voltagegated cation channels allows the regulated flow of cations such as Na+ K+ and Ca2+ across cell membranes which steers essential physiological processes including shaping of action potentials and triggering Ca2+dependent processes Classical textbooks describe the voltagegated cation channels as membrane proteins with a single central aqueous pore In recent years however evidence has accumulated for the existence of additional ion permeation pathways in this group of cation channels distinct from the central pore which here we collectively name noncanonical pores Whereas the first noncanonical pores were unveiled only after making specific point mutations in the voltagesensor region of voltagegated Na+ and K+ channels recent evidence indicates that they may also be functional in nonmutated channels Moreover several channelopathies have been linked to mutations that cause the appearance of a noncanonical ion permeation pathway as a new pathological mechanism This review provides an integrated overview of the biophysical properties of noncanonical pores described in voltagedependent cation channels KV NaV Cav Hv1 and TRPM3 and of the pathophysiological impact of opening of such poresWe thank all members of the Laboratory of Experimental Gynecology and the members of the Laboratory of Ion Channel Research for helpful discussions This work was supported by grants from the Belgian Federal Government IUAP P7/13 to TV the Research FoundationFlanders G056507 and G082511 to TV JV and G084515N to JV and the Research Council of the KU Leuven PFTRPLe to TV KH is funded by the FWO Belgium
Keywords:
.
|
Other Papers In This Journal:
|