Total saponins from dioscorea septemloba thunb red

Authors: Yan Chen Xiaolin Chen Ting Xiang Baoguo Sun Haoxuan Luo Mengting Liu Zexiong Chen Shijun Zhang Changjun Wang

Publish Date: 2016/04/13

Volume: 36, Issue: 2, Pages: 237-242

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Abstract

The aim of this study is to evaluate the efficacy of total saponins of Dioscorea TSD an extract of the Chinese herbal Bi Xie on hyperuricemia and to elucidate the underlying mechanisms The rat hyperuricemia model was established by administration of adenine Thirtytwo rats were randomly allocated into 4 groups model group low/highdose TSDtreated groups and allopurinoltreated group Meanwhile 8 rats were used as normal controls Serum uric acid UA blood urea nitrogen BUN serum creatinine Scr and organic anion transporting polypeptide 1A1 OATP1A1 levels were measured Comparison between the model group and treatment allopurinol and TSD groups showed the serum UA levels were significantly decreased in treatment groups TSD had similar effects to allopurinol It was found that the OATP1A1 protein expression levels in treatment groups were higher than in model group and normal controls And different from the allopurinoltreated groups TSDtreated group had elevated OATP1A1 expression levels in the stomach liver small intestine and large intestine tissues It was suggested that TSD may facilitate the excretion of UA and lower UA levels by upregulating OATP1A1 expressionThis project was supported by grants from the National Natural Science Foundation of China No 81072806 and No 81373500 Natural Science Foundation of Guangdong Province No S2012010009277 and Traditional Chinese Medicine Bureau of Guangdong Province No 20141046

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