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Title of Journal: Abdom Radiol

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Abbravation: Abdominal Radiology

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Springer US

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Value of diffusion-weighted MR imaging in the diagnosis of lymph node metastases in patients with cholangiocarcinoma

Authors: Konstantin Holzapfel, Jochen Gaa, Elaine C. Schubert, Matthias Eiber, Joerg Kleeff, Ernst J. Rummeny, Martin Loos,

Publish Date: 2016/06/07
Volume: 41, Issue:10, Pages: 1937-1941
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In 24 patients with cholangiocarcinoma, MR imaging of the upper abdomen was performed prior to surgery at 1.5 T using a respiratory-triggered single-shot echo-planar imaging (SSEPI) sequence (b values: 50, 300, and 600 s/mm2). ADC (apparent diffusion coefficient) values and diameters of regional lymph nodes (LN) were determined. Subsequently, in all patients, surgical exploration and/or resection of the primary tumor and regional LN dissection were performed. Imaging results were correlated with results of histopathologic analysis. ADC values and diameters of benign and malignant LN were compared using the Mann–Whitney U test. In addition, a ROC (receiver operating characteristic curve) analysis was performed.The mean ADC value (×10−3 mm2/s) of metastatic LN (1.21 ± 0.15) was significantly lower than that of benign LN (1.62 ± 0.33, p 



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