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Title of Journal: J Neurooncol

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Abbravation: Journal of Neuro-Oncology

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Springer US

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Age alone is not a predictor for survival in glioblastoma

Authors: Lucy Gately, Anna Collins, Michael Murphy, Anthony Dowling,

Publish Date: 2016/07/12
Volume: 129, Issue:3, Pages: 479-485
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Over half of glioblastoma (GBM) cases are diagnosed in patients older than 65 years. Their median overall survival (OS) is 4–5 months, compared with 12–14 months in patients younger than 70 years. This retrospective audit aims to identify patterns of care and survival of patients diagnosed with GBM at a single institution in Melbourne, Australia. Consecutive histological diagnoses of adult primary GBM from January 2010 to December 2012 were retrospectively identified from medical records. Demographic, treatment and survival characteristics were recorded until death, with follow-up to January 1st 2015. Survival was estimated by Kaplan–Meier method. Planned, sub-group analyses were conducted using multivariate Cox proportional hazards model to identify differences between elderly and younger cohorts, as well as ECOG. 165 patients were identified (36 % aged ≥70 years). Those ≥70 years had a poorer performance status (ECOG 3–4: 27 vs 10 %, p = .005); poorer median OS (2.6 vs 11.5 months, p  .05), after adjusting for other clinical factors. Significant predictors of poorer os were poor performance status (p = .001), bilateral tumours (p = .04), biopsy only (p = .001), and no adjuvant treatment (p 



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Other Papers In This Journal:

  1. Matrix metalloproteinase-1 expression enhances tumorigenicity as well as tumor-related angiogenesis and is inversely associated with TIMP-4 expression in a model of glioblastoma
  2. The effect of valproic acid in combination with irradiation and temozolomide on primary human glioblastoma cells
  3. Origins and clinical implications of the brain tumor stem cell hypothesis
  4. Genomic predictors of patterns of progression in glioblastoma and possible influences on radiation field design
  5. Suggested response criteria for phase II antitumor drug studies for neurofibromatosis type 2 related vestibular schwannoma
  6. Phase II trial of temozolomide in children with recurrent high-grade glioma
  7. Management of patients with recurrence of diffuse low grade glioma
  8. Valproic acid affected the survival and invasiveness of human glioma cells through diverse mechanisms
  9. Cognitive outcome as part and parcel of clinical outcome in brain tumor surgery
  10. The diagnostic accuracy of multiparametric MRI to determine pediatric brain tumor grades and types
  11. Do perfusion and diffusion MRI predict glioblastoma relapse sites following chemoradiation?
  12. Extraneural metastatic medulloblastoma in an adult
  13. Application of diffusion-weighted magnetic resonance imaging to predict the intracranial metastatic tumor response to gamma knife radiosurgery
  14. Tissue thioredoxin reductase-1 expression in astrocytomas of different grades
  15. Disparities in receipt of modern concurrent chemoradiotherapy in glioblastoma
  16. Multiple paraneoplastic diseases occurring in the same patient after thymomectomy
  17. Age alone is not a predictor for survival in glioblastoma

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