Effects of IL6 and cortisol fluctuations in post

Authors: Xiaofan Zhang Wei Zou Yuan Yang

Publish Date: 2016/10/18

Volume: 36, Issue: 5, Pages: 732-735

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Abstract

Depression is an important poststroke sequela with negative impact on mortality functional outcome and quality of life Changes in cytokines have been hypothesized to be associated with the etiology of poststroke depression PSD The altere dhypothalamicpituitaryadrenal HPA functioning is associated with the onset of depression The activity of HPA could induce the fluctuations of cortisol levels In this study we prospectively checked interleukin 6 IL6 and cortisol levels in patients with early ischemic stroke It was hypothesized that early serum IL6 and cortisol fluctuations in stroke patients were the predictions of PSD Totally 100 participants were selected from stroke inpatients consecutively admitted to the Department of Neurology Tongji Hospital from July 2014 to December 2015 Fifty health people served as the controls The serum of all the patients was collected at 800 am and 400 pm respectively one week after stroke The serum of controls was collected only at 800 am The levels of IL6 were analyzed by enzymelinked immunosorbent assay kit and those of cortisol were detected by chemiluminescence immunoassay On the 3rd week after stroke the patients were enrolled to the PSD group and nonPSD group based on the Diagnostic and Statistical Manual of Mental Disorders DSMIV and The Hamilton Depression Rating Scale HAMD21 score7 The IL6 level 1324±289 ng/L was elevated significantly in PSD groups as compared with that in nonPSD group and control group respectively P005 for both but there was no significant difference in the IL6 level between nonPSD group and control group The patients in both PSD group and nonPSD group had significantly elevated morning cortisol levels in comparison with those in the control group P005 for PSD nonPSD and control 50886±11951 42083±7004 and 34040±7630 nmol/L respectively Moreover afternoon cortisol levels in PSD group were significantly higher than those in nonPSD group and the morning baseline cortisol levels in these two groups were similar P005 It was suggested that PSD generally runs a chronic course and is related to a variety of adverse health outcomes including increased disability morbidity and mortality This study will help the screening of potential PSD in the early stage

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