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Title of Journal: Lifetime Data Anal

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Abbravation: Lifetime Data Analysis

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Springer US

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DOI

10.1007/bf02845517

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1572-9249

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Twophase outcomedependent studies for failure ti

Authors: J F Lawless
Publish Date: 2016/11/29
Volume: 24, Issue: 1, Pages: 28-44
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Abstract

Two or multiphase study designs are often used in settings involving failure times In most studies whether or not certain covariates are measured on an individual depends on their failure time and status For example when failures are rare case–cohort or case–control designs are used to increase the number of failures relative to a random sample of the same size Another scenario is where certain covariates are expensive to measure so they are obtained only for selected individuals in a cohort This paper considers such situations and focuses on cases where we wish to test hypotheses of no association between failure time and expensive covariates Efficient score tests based on maximum likelihood are developed and shown to have a simple form for a wide class of models and sampling designs Some numerical comparisons of study designs are presentedThis research was supported by a grant to the author from the Natural Sciences and Engineering Research Council of Canada DG RGPIN8597 The author thanks Kerai Lee for implementing the simulation studies in Section 4 and Shelley Bull and Yildiz Yilmaz for helpful comments on the study in Section 42


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