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Title of Journal: J Comput Neurosci

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Abbravation: Journal of Computational Neuroscience

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Springer US

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DOI

10.1002/sce.3730380357

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1573-6873

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The relationship between nernst equilibrium variab

Authors: Stephen R Meier Jarrett L Lancaster Dustin Fetterhoff Robert A Kraft Robert E Hampson Joseph M Starobin
Publish Date: 2016/12/01
Volume: 42, Issue: 2, Pages: 167-175
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Abstract

Spatiotemporal patterns of action potentials are considered to be closely related to information processing in the brain Autogenerating neurons contributing to these processing tasks are known to cause multifractal behavior in the interspike intervals of the output action potentials In this paper we define a novel relationship between this multifractality and the adaptive Nernst equilibrium in hippocampal neurons Using this relationship we are able to differentiate between various drugs at varying dosages Conventional methods limit their ability to account for cellular charge depletion by not including these adaptive Nernst equilibria Our results provide a new theoretical approach for measuring the effects which drugs have on singlecell dynamics

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