Authors: Jianbo Zhou Qingqing Wang Hangyi Lu Quan Zhang Pengfei Lv Qufu Wei
Publish Date: 2016/12/03
Volume: 17, Issue: 11, Pages: 1835-1841
Abstract
Biocompatible polyvinyl alcohol PVAstyrylpyridinium SbQ/βcyclodextrin βCD composite nanofibers were obtained by electrospinning in this study PVASbQ was used as the foundation polymer as well as crosslinking agent βCD was incorporated to achieve expected properties such as improved mechanical properties and thermal stability The Fourier transform infrared spectroscopy FTIR spectra confirmed the existence of βCD and the morphologies and average fiber diameters of the electrospun composite nanofibers were also analyzed by SEM Xray diffraction patterns XRD of PVASbQ/βCD composite nanofibers revealed that the inclusion of βCD in the nanofibers affected the ordered phase of PVA Besides the thermal analyses revealed the improvement in the thermal properties for PVASbQ/βCD composite nanofibers It was found that the crosslinked composite nanofibers showed a clear higher tensile strength TS as well as a greater elongation at break EB Eventually antifungal drug griseofulvin GSV has been loaded into the composite nanofibers by formation of its inclusion complex with βCD in aqueous solution ultraviolet light UVVis spectral analysis showed that the drugloading nanofibers had certain sustained release effect
Keywords: