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Title of Journal: J Interv Card Electrophysiol

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Abbravation: Journal of Interventional Cardiac Electrophysiology

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Springer US

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Predictors of serious arrhythmic events in patients with nonischemic heart failure

Authors: Mauricio Pimentel, André Zimerman, Diego Chemello, Vanessa Giaretta, Michael Andrades, Daiane Silvello, Leandro Zimerman, Luis E. Rohde,

Publish Date: 2016/12/10
Volume: 48, Issue:2, Pages: 131-139
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Risk stratification of serious arrhythmic events in patients with nonischemic heart failure (HF), beyond estimates of left ventricular ejection fraction (LVEF), remains an important clinical challenge. This study aims to determine the clinical value of different noninvasive and invasive tests as predictors of serious arrhythmic events in patients with nonischemic HF.A prospective observational study was conducted including 106 nonischemic HF patients who underwent a comprehensive clinical and laboratory evaluation including two-dimensional echocardiography, 24-h Holter monitoring, cardiopulmonary exercise testing (CPX), and an invasive electrophysiological study. The study’s primary end-point was either syncope, appropriate therapy by implantable cardioverter-defibrillators, or sudden cardiac death.During a mean follow-up of 704 ± 320 days, the primary end-point occurred in 15 patients (14.2%). In multivariable analysis, LV end-diastolic diameter >73 mm (hazard ratio [HR] 3.7; p = 0.016), exercise periodic breathing (EPB) on CPX (HR 2.88; p = 0.045), and non-sustained ventricular tachycardia (NSVT) ≥10 beats (HR 8.2; p 



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