Authors: Xia Cao Jiansong Zhou Hong Yuan Zhiheng Chen
Publish Date: 2016/03/31
Volume: 42, Issue: 1, Pages: 127-134
Abstract
Nonalcoholic fatty liver NAFLD usually has worse cardiovascular risk factors Given the potential association between deterioration of sleep and arterial stiffness we aim to investigate the association between deterioration of sleep and arterial stiffness in a middleaged Chinese population with NAFLD In this crosssectional study 15372 Chinese aged 40–60 years who participated in periodic health checkups in central south China were included Selfreported sleep duration and sleep quality anthropometric biochemical and liver ultrasound scan were analyzed and brachialankle pulse wave velocity baPWV was used as the indicator of arterial stiffness Poor sleep quality was found to be associated with increased arterial stiffness with odds ratios and 95 confidence intervals CIs of 228 95 CI 153–338 compared with good sleep quality Using sleep duration ≥ 8 h as the reference there was no significant association between sleep duration of ≤ 6 or 6–8 h and arterial stiffness after multivariableadjusted In additional analyses further investigation of the association of different combinations of sleep duration and quality in relation to arterial stiffness indicated participants with poor sleep quality and sleep duration ≤ 6 h were more likely to have arterial stiffness than those with good quality sleep who sleep for ≥ 8 h OR 259 95 CI 158–424 The present study indicates that short sleep duration poor sleep quality in individuals with NAFLD correlate with increased arterial stiffnessWe thank Chang Liu for his help in programming and statistical analyses as well as all participants for their contribution This work was supported in part by a grant from Key Science and Technology Projects in Hunan Province 2014SK3062 and a grant from Science and Technology Plan Projects 2013BAI04B00
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