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Authors: Yogambigai Velmurugu
Publish Date: 2017
Volume: , Issue: , Pages: 49-90
Abstract
Integration host factor IHF is a small hetero dimeric protein ~20 kDa ubiquitous in eubacteria It binds to DNA in a sequencespecific manner and causes ~35bp long cognate site of DNA to bend by 160° 1 Even though IHF was first discovered as a host factor for bacteriophage λ integration where λ phage cleverly facilitates its E coli host’s protein IHF to infest its target IHF also aids in chromosomal compaction as well as in the assembly of higher order nucleoprotein complexes necessary for replication initiation some sitespecific recombination and transcriptional regulation of certain genes 2 3
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