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Authors: Ceu Figueiredo M C Camargo Marina Leite Ezequiel M FuentesPananá Charles S Rabkin José C Machado
Publish Date: 2017
Volume: , Issue: , Pages: 277-304
Abstract
Gastric cancer is the fifth most incident and the third most common cause of cancerrelated death in the world Infection with Helicobacter pylori is the major risk factor for this disease Gastric cancer is the final outcome of a cascade of events that takes decades to occur and results from the accumulation of multiple genetic and epigenetic alterations These changes are crucial for tumor cells to expedite and sustain the array of pathways involved in the cancer development such as cell cycle DNA repair metabolism celltocell and celltomatrix interactions apoptosis angiogenesis and immune surveillance Comprehensive molecular analyses of gastric cancer have disclosed the complex heterogeneity of this disease In particular these analyses have confirmed that Epstein–Barr virus EBVpositive gastric cancer is a distinct entity The identification of gastric cancer subtypes characterized by recognizable molecular profiles may pave the way for a more personalized clinical management and to the identification of novel therapeutic targets and biomarkers for screening prognosis prediction of response to treatment and monitoring of gastric cancer progression
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