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Authors: Jesse W Rowley Bhanu Kanth Manne Andrew S Weyrich
Publish Date: 2017
Volume: , Issue: , Pages: 227-238
Abstract
Until recently platelets were categorized as simple anucleate cytoplasts that function solely in the hemostatic arena However the last decade has demonstrated that platelets have roles beyond primary hemostasis and they possess complex molecular information including a rich repertoire of messenger RNAs mRNAs Platelet mRNAs have features that mirror transcripts produced and translated in nucleated cells and mRNAs for approximately half of the human genome have been identified in this terminally differentiated cell The study of platelet mRNAs has expanded tremendously with the advent of nextgeneration RNA sequencing NGS and several groups have shown that platelets are capable of translating some megakaryocytederived mRNAs into protein Platelet mRNA profiles have also been used to predict cellular function and platelets are capable of transferring intact mRNAs into microparticles and other cells This chapter reviews our current understanding of platelet mRNAs and their potential contribution to biological and pathologic processes in humans Roles for noncoding RNAs are described in Edelstein and Bray 2017
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