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Authors: Patricia DomínguezCuevas Silvia Marqués
Publish Date: 2017
Volume: , Issue: , Pages: 1-22
Abstract
The TOL plasmidencoded pathway for the degradation of toluene and derivatives is an archetype in bacterial transcription regulation Six promoters belonging to different classes and several chromosome and plasmidencoded proteins are involved in maintaining optimal expression levels and synchronization with the global cell metabolism The TOLencoded regulators are the enhancerbinding protein XylR which controls the σ54dependent promoters of the upper pathway Pu and of xylS gene PS1 and the AraC family regulator XylS which controls the σ32σ38dependent metacleavage pathway promoter Pm Both regulators respond to the presence of a specific effector and activate transcription through different mechanisms Much effort has been devoted to the elucidation of these processes In this review recent results are described and discussed in the light of the latest findings and models for homologous family proteins and their interrelationships with the cell metabolisma The pWW0 TOL plasmid aromatic degradation pathway is organized in two operons and two regulatory genes included in two transposable elements inserting one within another b Schematic presentation of XylR modular organization into three functional domains a sensor domain A connected by a linker B to the central or AAA+ domain C and a DNAbinding domain D c Schematic presentation of the XylS protein functional domains effector binding and dimerization domain and DNAbinding domain containing two HTH motives The residue numbers delimiting each domain are indicated in each case
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