Combining a Patchbased Approach with a Nonrigid

Authors: Carlos Platero M Carmen Tobar

Publish Date: 2017/01/28

Volume: 15, Issue: 2, Pages: 165-183

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Abstract

We provide and evaluate an opensource software solution for automatically hippocampal segmentation from T1weighted T1w magnetic resonance imaging MRI The method is applied for measuring the hippocampal volume which allows discriminate between patients with Alzheimer’s disease AD or mild cognitive impairment MCI and elderly controls NC The method is based on a fast patchbased label fusion method whose selected patches and their weights are calculated from a combination of similarity measures between patches using intensitybased distances and labelingbased distances These combined similarity measures produces better selection of the patches and their weights are more robust The algorithm is trained with the Harmonized Hippocampal Protocol HarP The proposal is compared with FreeSurfer and other label fusion methods To evaluate the performance and the robustness of the proposed label fusion method we employ two databases of T1w MRI of human brains For AD vs NC we obtain a high degree of accuracy approximately 90 For MCI vs NC we obtain accuracies around 75 The average time for the hippocampal segmentation from a T1w MRI is less than 17 minutesData collection for this study was funded by the ADNI National Institutes of Health Grant U01 AG024904 and the Laboratory of Cognitive and Computational Neuroscience LCCN of the Center of Biomedical Technology Technical University of Madrid ADNI is funded by the National Institute on Aging the National Institute of Biomedical Imaging and Bioengineering and and through generous contributions from the following Alzheimer’s Association Alzheimer’s Drug Discovery Foundation BioClinica Inc Biogen Idec Inc BristolMyers Squibb Company Eisai Inc Elan Pharmaceuticals Inc Eli Lilly and Company F HoffmannLa Roche Ltd and its affiliated company Genentech Inc GE Healthcare Innogenetics NV IXICO Ltd Janssen Alzheimer Immunotherapy Research Development LLC Johnson Johnson Pharmaceutical Research Development LLC Medpace Inc Merck Co Inc Meso Scale Diagnostics LLC NeuroRx Research Novartis Pharmaceuticals Corporation Pfizer Inc Piramal Imaging Servier Synarc Inc and Takeda Pharmaceutical Company

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