Central and Peripheral Neural Targets for Neurosti

Authors: Massimo Leone Alberto Proietti Cecchini

Publish Date: 2017/03/07

Volume: 21, Issue: 3, Pages: 16-

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Abstract

Chronic headache sufferers are estimated to be around 3 of the population These patients have a high disease burden When prophylactic treatments have low efficacy and tolerability patients are in need of alternative therapeutic strategies and optionsIn the last decade a number of neuromodulation procedures have been introduced as treatment of chronic intractable headache patients when pharmacological treatments fail or are not well tolerated Neurostimulation of peripheral and central nervous system has been carried out and now various noninvasive and invasive stimulation devices are available Noninvasive neurostimulation options include vagus nerve stimulation supraorbital stimulation and singlepulse transcranial magnetic stimulation invasive procedures include occipital nerve stimulation sphenopalatine ganglion stimulation and hypothalamic deep brain stimulation In many cases results supporting their use derive from openlabel series and small controlled trial studies Lack of adequate placebo hampers adequate randomized controlled trials

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