Journal Title
Title of Journal: Arch Intern Med
|
Abbravation: Archives of Internal Medicine
|
Publisher
American Medical Association
|
|
|
|
|
|
Authors: ALVIN R TARLOV GEORGE J BREWER PAUL E CARSON ALF S ALVING
Publish Date: 1962/02/01
Volume: 109, Issue: 2, Pages: 209-234
Abstract
The potential danger of hemolysis from use of the 8aminoquinoline antimalarial drug pamaquine Plasmoquine has been known since 19261 Earle2 in 1948 reported that pamaquine caused hemolysis in 510 of American Negroes but rarely in Caucasians Similar observations were made in 1952 by Hockwald3 during an evaluation of the related but less toxic drug primaquine it was further noted that the severity of hemolysis was determined by the amount of drug administered In 1954 Dern4 discovered that the susceptibility to hemolysis by primaquine is due to an intrinsic abnormality of the erythrocyte Dern Beutler and Alving5 reported that the hemolysis is selflimited in that clinical recovery occurs even if the daily dose of drug is continued Many drugs can precipitate hemolysis6 This hypersusceptibility to hemolysis by drugs is a genetically transmitted inborn error of metabolism7 The first biochemical abnormality to characterize drugsensitive cellsTARLOV AR BREWER GJ CARSON PE ALVING AS Primaquine Sensitivity Glucose6Phosphate Dehydrogenase Deficiency An Inborn Error of Metabolism of Medical and Biological Significance Arch Intern Med 19621092209–234 doi101001/archinte196203620140081013
Keywords:
References
citation title=Genetic Control of Glucose6Phosphate Dehydrogenase Production citation author=Porter I H Boyer S H Schulze J and McKusick V A citation book=Proceedings of the Second International Conference of Human Genetics Rome 1961
.
|
Other Papers In This Journal:
|