Comparative In Vitro Activity of Faropenem and 11

Authors: J W Decousser P Pina F Picot P Y Allouch

Publish Date: 2003/08/27

Volume: 22, Issue: 9, Pages: 561-565

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Abstract

The aim of the study presented here was to evaluate the in vitro activity of faropenem a new member of the penem class intended for oral administration compared with 11 other antimicrobial agents against a large number of Streptococcus pneumoniae strains isolated from adults and children with bloodstream infections in France The minimum inhibitory concentration of faropenem against 90 of the pediatric strains tested was generally one to two dilutions lower than the most potent betalactam agents ie 05 µg/ml for faropenem vs 1 for amoxicillin 1 for cefotaxime and 05 µg/ml for ceftriaxone Against the adult strains only moxifloxacin had a MIC90 value similar to faropenem ie 025 µg/ml for both agents Faropenem seems to be a promising antimicrobial agent for the treatment of adult and pediatric Streptococcus pneumoniae infectionsThe authors would like to thank the following laboratories for providing clinical isolates for use in the study Pediatric Streptococcus pneumoniae strains A Collignon Centre HospitaloUniversitaire Jean Verdier Bondy C Chaplain Centre Hospitalier Saint Denis A Fremaux and E Estrangin Centre Hospitalier Intercommunal Créteil JC Ghnassia Hôpital A Mignot Versailles Adult Streptococcus pneumoniae strains A Mandjee Centre Hospitalier Romans M Marcolin Centre Hospitalier dArras M Morillon Hôpital des Armées Laveran Marseille G Otterbein Hôpital Sainte Camille Bry sur Marne B Pangon Hôpital A Mignot Versailles JG Paul Centre Hospitalier Duchenne Boulogne sur Mer N Peyrard Centre Hospitalier Beaune D Pierrejean Centre Hospitalier Auch P Pouedras CHP Chubert Vannes G Rast Centre Hospitalier Intercommunal Poissy JC Reveil and C Auvray Centre Hospitalier Charleville Mezieres P Roos Hôpital Bel Air Thionville O Sabot Centre Hospitalier Belley S Samaille Centre Hospitalier Saint Omer R Sanchez Centre Hospitalier Perigueux A Secher Centre Hospitalier Chartres H Senechal Centre Hospitalier Quimperle H SepHieng Centre Hospitalier Avranches DP Simeon Centre Hospitalier Langres A Vachée Centre Hospitalier Roubaix E Vallée Centre Hospitalier Eaubonne J Vaucel Centre Hospitalier la Beauchée SaintBrieuc M Villemain Centre Hospitalier Aurillac C Cattoen Centre Hospitalier Général Valenciennes AM Astoul Centre Hospitalier Général Brive La Gaillarde J TexierMaugin Hôpital Haut Lévèque Pessac G Aubert Hôpital Bellevue SaintEtienne J Cottin Hôpital Hôtel Dieu Angers A Le Faou Hôpital dAdulte Vandoeuvre Les Nancy JF Lemeuland Hôpital Charles Nicolle Rouen F Eb Groupe Hospitalier Nord Amiens JL Fauchere Cité Hospitalière de la Milètrie Poitiers J Akli Centre Hospitalier Général Blois I Baudinat Centre Hospitalier Chalons en Champagne E Bichier Centre Hospitalier Saumur H Biessy Centre Hospitalier St Louis La Rochelle M Bietrix Centre Hospitalier Général Martigues C BouguignySaison Centre Hospitalier Soissons P Brisou Hôpital des Armées St Anne Toulon Naval J CarreCavelier Centre Hospitalier Bayeux P Chantelat Centre Hospitalier Paul Morel Vesoul C Chaplain Centre Hospitalier SaintDenis M Cheron Centre Hospitalier SaintGermainenLaye MF Danjoux Centre Hospitalier Intercommunal Tarbes F Delubac Centre Hospitalier Annonay H Demontclos Centre Hospitalier Bourg en Bresse Y Rio and J Didion Hôpital Notre Dame de Bon Secours Metz G Chambreuil Centre Hospitalier départemental La Roche Sur Yon J Dublanchet Centre Hospitalier Intercommunal Villeneuve Saint Georges B Dubourdieu Centre Hospitalier Rodez JC Croix Centre Hospitalier Troyes P Emerique Centre Hospitalier Remiremont JL Flipo Centre Hospitalier Wissembourg A Fremaux Centre Hospitalier Intercommunal Creteil M Gavignet Centre Hospitalier Jacques Coeur Bourges F Geffroy Centre Hospitalier Laënnec Quimper A Kazmierczak Hôpital du Bocage Dijon P Guiet Centre Hospitalier Nemours E Jaquen Centre Hospitalier SablesurSarthe P Plesiat Hôpital Jean Minjoz Besancon E Laurens Centre Hospitalier Cholet A Le Coustumier Centre Hospitalier Cahors F Leturdu Centre Hospitalier V Dupouy Argenteuil V Macchi Centre Hospitalier SaintVallier C Malbrunot Centre Hospitalier Corbeil Essonnes

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