Cytogenetic Findings in Pediatric TLymphoblastic

Authors: Dale A Ellison David M Parham Jeffrey R Sawyer

Publish Date: 2005/10/05

Volume: 8, Issue: 5, Pages: 550-556

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Abstract

Cytogenetic analyses of lymphomas commonly reveal nonrandom chromosomal abnormalities but there are relatively few reports in childhood lymphoblastic lymphoma LL We retrospectively reviewed Gbanded karyotypic analyses performed at Arkansas Children’s Hospital between 1990 and 2004 Six children 2 to 20 years old had LL that presented as mediastinal or cervical masses and had a Tcell immunophenotype and clonal abnormalities The cytogenetic findings in these 6 patients were as follows 46XX−7inv9p11q12der 12t712q112p13t1618p131q21+22 in patient 1 47XX+9del9q11q22x2 in patient 2 72−119 XY+X+1+1 inv2 p11q13−3+5+6+7+10−12−16 −21−21−22+mar in patient 3 48XY+5+20t79 q32q34 in patient 4 47∼48XXder10t1014q23 q112+12 del12p12x2 −14del16q22q22+add 19p133 in patient 5 and 48∼49XY+7+8t1119 q23p133+der19t1119cp20 in patient 6 Eleven chromosome breakpoints in 6 of our patients 7q11 12p13 16p13 18q21 9q11 2p11 2q13 7q32 and 7q23 have been reported in other patients with acute lymphoblastic leukemia or LL and involved regions containing TEL ABL E2A MLL and Tcell receptorα genes A review of the cytogenetic findings of these and other cases of LL reveals that clonal aberrations are common and most frequently involve Tcell receptor gene regions The aberrations show some features similar to those of acute lymphoblastic leukemia and are not unique to LL thus furnishing additional evidence of the equivalence of these two diseases The cytogenetic features of LL may be helpful in the diagnosis of pediatric lymphomas and undifferentiated neoplasms

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