Authors: L H Jacobson J F Cryan
Publish Date: 2006/09/23
Volume: 37, Issue: 1, Pages: 171-213
Abstract
Depression is a growing pandemic in developed societies The use of inbred mouse strains in preclinical psychiatric research has proven to be a valuable resource Firstly they provide the background for genetic manipulations that aid in the discovery of molecular pathways that may be involved in major depression Further inbred mouse strains are also being used in the determination of genetic and environmental influences that may predispose or trigger depressionrelated behavior This review aims to highlight the utility of inbred mouse strains in depression research while providing an overview of the current state of research into behavioral differences between strains in paradigms commonly used in the field Neurochemical differences that may underlie strain differences are examined and some caveats and cautions associated with the use of inbred strains are highlighted
Keywords: