G×E Interaction Influences Trajectories of Hand Gr

Authors: Inge Petersen Nancy L Pedersen Taina Rantanen William S Kremen Wendy Johnson Matthew S Panizzon Lene Christiansen Carol E Franz Matt McGue Kaare Christensen Nayla R Hamdi Robert F Krueger Chandra Reynolds

Publish Date: 2015/08/29

Volume: 46, Issue: 1, Pages: 20-30

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Abstract

Agerelated decline in grip strength predicts later life disability frailty lower wellbeing and cognitive change While grip strength is heritable genetic influence on change in grip strength has been relatively ignored with nonshared environmental influence identified as the primary contributor in a single longitudinal study The extent to which geneenvironment interplay particularly geneenvironment interactions contributes to grip trajectories has yet to be examined We considered longitudinal grip strength measurements in seven twin studies of aging in the Interplay of Genes and Environment across Multiple Studies consortium Growth curve parameters were estimated for samesex pairs aged 34–99 N = 10681 Fisher’s test for mixture distribution of withinmonozygotic twinpair differences N = 1724 was performed on growth curve parameters We observed significant geneenvironment interaction on grip strength trajectories Finally we compared the variability of withinpair differences of growth curve parameters by APOE haplotypes Though not statistically significant the results suggested that APOE ɛ2ɛ2/ɛ2ɛ3 haplotypes might buffer environmental influences on grip strength trajectoriesIGEMS is supported by the National Institutes of Health grant No R01 AG037985 SATSA was supported by grants R01 AG04563 R01 AG10175 the MacArthur Foundation Research Network on Successful Aging the Swedish Council For Working Life and Social Research FAS 9701471B 20090795 and Swedish Research Council 82520077460 82520096141 OCTOTwin was supported by grant R01 AG08861 The Danish Twin Registry is supported by grants from The National Program for Research Infrastructure 2007 from the Danish Agency for Science Technology and Innovation the Velux Foundation and the US National Institute of Health P01 AG08761 VETSA was supported by National Institute of Health grants NIA R01 AG018384 R01 AG018386 R01 AG022381 and R01 AG022982 and in part with resources of the VA San Diego Center of Excellence for Stress and Mental Health The Cooperative Studies Program of the Office of Research Development of the United States Department of Veterans Affairs has provided financial support for the development and maintenance of the Vietnam Era Twin Registry The MIDUS study was supported by the John D and Catherine T MacArthur Foundation Research Network on Successful Midlife Development and by National Institute on Aging Grant AG20166 FITSA was supported by grants from the Academy of Finland 69818 and the Finnish Ministry of Education and Culture 120/722/2003

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