Association between polymorphisms of biotransforma

Authors: ChihChing Yeh FungChang Sung Reiping Tang Chung Rong ChangChieh LingLing Hsieh

Publish Date: 2006/12/27

Volume: 14, Issue: 2, Pages: 183-193

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Abstract

The relationship between diet and colorectal cancer has been previously demonstrated and supported with strong epidemiological evidence The role of genetic polymorphisms has however been less well elaborated upon We conducted a hospitalbased case–control study including 727 cases and 736 healthy controls to evaluate the associations of the polymorphic phaseI and II biotransformations CYP1A1 CYP1A2 GSTM1 GSTT1 GSTP1 NAT1 and NAT2 and DNArepair enzymes XRCC1 XRCC3 and XPD with the risk of contracting colorectal cancer We found that men featuring the CYP1A12C G/G genotype the GSTT1 null genotype and XPD 751 with the Gln allele were associated with an elevated risk of colorectal cancer than were men who did not exhibit such genetic features Multivariate logistic regression analysis revealed that individuals featuring more than two highrisk genotypes increased the colorectalcancer risk 31fold OR = 31 95 CI = 18–52 For women subjects featuring the CYP1A12C G/G genotype and the XRCC3 Thr/Thr genotype faced a 31fold greater risk 95 CI = 13–70 of colorectal cancer when compared to those featuring the CYP1A12C A allele and the XRCC3 Met allele Taken together this study suggests that polymorphisms of genes involved in biotransformation and DNA repair could modulate colorectalcancer risk in TaiwanThis study was supported by Grant NSC 892314B002–373 NSC 902320B002123 and NSC 912320B002121 from the National Science Council and Grant DOH 85HR516 DOH 86HR516 and DOH 87HR516 from the National Health Research Institute Department of Health The Executive Yuan Republic of China

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