Epidemiology molecular epidemiology and risk fac

Authors: Chiara Paglino Ilaria Imarisio Bruno Rovereto

Publish Date: 2007/10/27

Volume: 1, Issue: 2, Pages: 120-127

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Abstract

Despite only accounting for approximately 2 of all new primary cancer cases renal cell carcinoma RCC incidence has dramatically increased over time Incidence rates vary greatly according to geographic areas so that it is extremely likely that exogenous risk factors could play an important role in the development of this cancerSeveral risk factors have been linked with RCC including cigarette smoking obesity hypertension and antihypertensive drugs chronic kidney diseases also dialysis and transplantation as well as the use of certain analgesics Furthermore although RCC has not generally been considered an occupational cancer several types of occupationallyderived exposures have been implicated in its pathogenesis These include exposure to asbestos chlorinated solvents gasoline diesel exhaust fumes polycyclic aromatic hydrocarbons printing inks and dyes cadmium and lead Finally families with a predisposition to the development of renal neoplasms were identified and the genes involved discovered and characterized Therefore there are now four wellcharacterized genetically determined syndromes associated with an increased incidence of kidney tumors ie Von Hippel Lindau VHL Hereditary Papillary Renal Carcinoma HPRC BirtHoggDubé Syndrome BHD and Hereditary Leiomyomatosis and Renal Cell Cancer HLRCC This review will address present knowledge about the epidemiology molecular epidemiology and risk factors of RCC

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