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Title of Journal: Radiol Phys Technol

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Abbravation: Radiological Physics and Technology

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Springer-Verlag

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DOI

10.1007/s001040050342

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1865-0341

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Experimental verification of proton beam monitorin

Authors: Teiji Nishio Aya Miyatake Kazumasa Inoue Tomoko GomiMiyagishi Ryosuke Kohno Satoru Kameoka Keiichi Nakagawa Takashi Ogino
Publish Date: 2007/11/27
Volume: 1, Issue: 1, Pages: 44-54
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Abstract

Proton therapy is a form of radiotherapy that enables concentration of dose on a tumor by use of a scanned or modulated Bragg peak Therefore it is very important to evaluate the protonirradiated volume accurately The protonirradiated volume can be confirmed by detection of pairannihilation gamma rays from positronemitting nuclei generated by the nuclear fragmentation reaction of the incident protons on target nuclei using a PET apparatus The activity of the positronemitting nuclei generated in a patient was measured with a PETCT apparatus after proton beam irradiation of the patient Activity measurement was performed in patients with tumors of the brain head and neck liver lungs and sacrum The 3D PET image obtained on the CT image showed the visual correspondence with the irradiation area of the proton beam Moreover it was confirmed that there were differences in the strength of activity from the PETCT images obtained at each irradiation site The values of activity obtained from both measurement and calculation based on the reaction cross section were compared and it was confirmed that the intensity and the distribution of the activity changed with the start time of the PET imaging after proton beam irradiation The clinical use of this information about the positronemitting nuclei will be important for promoting proton treatment with higher accuracy in the futureWe greatly thank the staff members of the Proton Radiotherapy Department of the National Cancer Center Kashiwa for their assistance and the members of SHI Accelerator Service Ltd and Accelerator Engineering Inc for operation of the proton apparatus We are grateful to the reviewers and editors of this Journal for their comments and advices and thank the other office staffs for their supports

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