Usefulness of standardized uptake value normalized

Authors: Atsushi Narita Susumu Shiomi Yutaka Katayama Takashi Yamanaga Hiromitsu Daisaki Kazuo Hamada Yasuyoshi Watanabe

Publish Date: 2016/02/12

Volume: 9, Issue: 2, Pages: 170-177

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Abstract

Our aim in this study was to verify the usefulness of the standardized uptake value SUV normalized by individual CTbased lean body mass LBMCT in application of PET response criteria in solid tumors PERCISTWe retrospectively investigated 14 patients 4 male and 10 female with malignant lymphoma who were undergoing chemotherapy 18FFDG PET/CT examinations were performed before and after chemotherapy The LBMCT was calculated by estimation of fat weight from CT data from skull base to pelvis The mean ± standard deviation SD and the Bland–Altman plot were used for comparison among body weight LBMCT and LBM derived from a predictive equation LBMPE Indices for FDG uptake in the liver were SUV SUV based on LBMPE SULPE and SUV based on LBMCT SULCT Overall differences between the uptake values were analyzed by oneway ANOVA If the ANOVA showed significance differences between uptake values were investigated further by use of the Tukey–Kramer test The mean values of body weight LBMPE and LBMCT were 554 ± 149 390–1120 430 ± 105 313–752 and 353 ± 98 234–758 kg respectively There was a wide dispersion between LBMPE and LBMCT differences 76 ± 36 kg 95  CI 642–885 LBMPE was higher than LBMCT in all the cases except in Case 11 The mean uptake values significantly differed among SUV SULPE and SULCT F = 683 p  005 Whereas SULPE deviated from PERCIST criteria in seven patients SULCT satisfied the criteria except in one case These results suggest that liver SULCT is useful for application of PERCIST

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