Authors: Mike T Christensen
Publish Date: 2008/10/29
Volume: 25, Issue: 11, Pages: 1191-1199
Abstract
Because of the added emphasis on ocular surface damage included in the Dry Eye Workshop’s revised definition of dry eye an evaluation of corneal staining reductions was conducted for propylene glycol/polyethylene glycol 400based artificial tear drops Systane® Lubricant Eye Drops Alcon Laboratories Fort Worth TX USAAn analysis was conducted on the percent change from baseline in mean corneal staining scores as reported in two previously published randomized doublemasked 6week clinical studies of Systane A descriptive comparison was also made between the outcome of the composite analysis and data obtained for Optive™ Lubricant Eye Drops Allergan Inc Irvine CA USA Finally results were reviewed for an openlabel study that investigated corneal staining over a 5week period after patients discontinued Systane therapyThe composite analysis included 107 Systanetreated patients The results showed that Systane consistently reduced corneal staining at each visit the percent change from baseline to day 42 exit was 471 P00001 After discontinuing Systane immediate and significant increases in corneal staining were reported by 20 patients with an overall increase from baseline to day 35 exit of 1950 P00001Evaluations of sum corneal ocular staining scores provide clinically meaningful evidence of dry eye severity and are an important indicator of dry eye disease progression The results of the composite analysis of two peerreviewed studies indicate that Systane significantly reduced corneal staining P00001 indicating a reduction in the severity of dry eye Finally discontinuation of Systane results in a rapid increase in corneal staining that further confirms Systane’s ability to maintain ocular surface health
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